Craig M. Crews Receives the 2023 Bristol Myers Squibb Award in Enzyme Chemistry

Professor Craig M. Crews, John C. Malone Professor of Molecular, Cellular and Developmental Biology at Yale University is the recipient of the 2023 Bristol Myers Squibb Award in Enzyme Chemistry. He also holds joint appointments in the departments of Chemistry and Pharmacology and is the Executive Director of the Yale Center for Molecular Discovery.

Established in 2023, the Bristol Myers Squibb Award in Enzyme Chemistry was created to recognize a prominent scientist whose research accomplishments in biochemistry or chemical biology are unusually significant and far-reaching. The Award is administered by the Division of Biological Chemistry (DBC) of the American Chemical Society (ACS) and generously sponsored by Bristol Myers Squibb.

In his lab, Crews is primarily focused on chemical approaches to control cellular systems. As stated in his Yale School of Medicine profile, “We develop novel reagents and methodologies, which will allow us to explore new areas in cell biology. This 'chemical genetic' approach uses biologically active small molecules to control various intracellular processes. For example we developed the PROTAC technology that decrease target protein levels within cells by inducing their proteolysis via the 26S proteasome. A goal of this research is to develop novel methodologies that would allow for small molecule control of the 'undruggable proteome’.”

Please join us in congratulating Professor Cews for this outstanding achievement!